of course you can do that.
This isn't one setting - FO:E has literally one setting, post-apocalyptic. Things can be shitty or worse, but if they're shining and new then shits on fire, yo.
CB is much looser, or it always has been. Play it for yucks, subvert it, invert it, screw with it - it's all good.
We've got my frivolous shameless stuff involving orgies on the beach, chat's stuff involving deeper introspective meaning-of-being-human plots, ten rounds universe where the humans are fighting tooth and nail to eradicate the cute zombies that just want to help, we've got the humanification bureau that has those corrupted and evil ponies becoming sinless, enlightened humans.
That's the thing, we've never centralized on one canon setting, so pick what you want to tell a story about and make it happen,
Personally, there's great room for black comedy pieces about people going pony because of toothaches, or being slipped potion in their drink and getting fired from work - reinvent it even, make earth a paradise and make ponies want to be human.
It's all good, just don't be a douche and call them all misanthropic wish fulfillment, it just shows your ignorance. Plenty are, sure, but hey, so's most fanfiction.
I call it shit when I see shit and the author in question can't. When the author is trying hard, knows s/he has to improve, then CB or not, encourage, help improve. Ripping the piss is reserved for those without a brain, not for those who need (Even a lot of) improvement.